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| カタログ番号 | HW471014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TIMP3 Polyclonal Antibody (HW471014) is a rabbit polyclonal antibody detecting TIMP3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Equus caballus.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TIMP3 (Cys24-Pro211). | ||||||||
| ターゲット | Protein MIG-5, TIMP-3, Tissue inhibitor of metalloproteinases 3, TIMP3, Metalloproteinase inhibitor 3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P35625 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Metalloproteinase inhibitor 3 (TIMP3) is a ~24 kDa protein. Mediates a variety of processes including matrix regulation and turnover, inflammation, and angiogenesis, through reversible inhibition of zinc protease superfamily enzymes, primarily matrix metalloproteinases (MMPs). Regulates extracellular matrix (ECM) remodeling through inhibition of matrix metalloproteinases (MMP) including MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Additionally, modulates the processing of amyloid precursor protein (APP) and apolipoprotein E receptor ApoER2 by inhibiting two alpha-secretases ADAM10 and ADAM17. Functions as a tumor suppressor and a potent inhibitor of angiogenesis. Exerts its anti-angiogenic effect by directly interacting with vascular endothelial growth factor (VEGF) receptor-2/KDR, preventing its binding to the VEGFA ligand. 1. Hoe, HS. et al. (2007) The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 10895-905. PMID: 17913923 2. Qi, JH. et al. (2003) Nature medicine 9, 407-15. PMID: 12652295 3. Qi, JH. et al. (2015) Apoptosis : an international journal on programmed cell death 20, 523-34. PMID: 25558000 | ||||||||
| 注意事項 | For research use only. |
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