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| カタログ番号 | VK009014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TMEV VP1 Polyclonal Antibody (VK009014) is a rabbit polyclonal antibody detecting VP1 in ELISA, IHC, WB.
Highlights
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| 種反応性 | Theiler's murine encephalomyelitis virus (TMEV) | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Theiler's murine encephalomyelitis virus VP1 (Gly647-Glu920). | ||||||||
| ターゲット | VP1 | ||||||||
| 純度 | >90% | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P13899 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Genome polyprotein, Leader protein, L, Capsid protein VP0, VP4-VP2, Capsid protein VP4, P1A, Virion protein 4, Capsid protein VP2, P1B, Virion protein 2, Capsid protein VP3, P1C, Virion protein 3, Capsid protein VP1, P1D, Virion protein 1, Protein 2A, P2A, Protein 2B, P2B, Protein 2C, P2C, EC:3.6.4.13, Protein 3A, P3A, VPg, P3B, Protein 3B, Protease 3C, P3C, EC:3.4.22.28, Picornain 3C, RNA-directed RNA polymerase, RdRp, EC:2.7.7.48, 3D polymerase, 3Dpol, Protein 3D, 3D | ||||||||
| 背景 | Genome polyprotein (VP1) is a ~256 kDa protein. Forms a complex with host RAN and probably binds to exportins carrying activated MAPK in order to mediate the hyperphosphorylation of host Phe/Gly containing nuclear pore proteins (Nups) resulting in cessation of active nucleocytoplasmic transport (Probable). Proteins with NLS signals fail to import, cellular mRNAs fail to export, and some proteins small enough for diffusion are not retained anymore (efflux). The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response. The leader protein also inhibits host interferon regulatory factor 3 (IRF3) dimerization, thereby blocking the transcriptional activation of IFN genes. Binds to host RNase L thereby preventing its activation by 2'-5' oligoadenylates in order to counteract the antiviral interferon-inducible OAS/RNase L pathway. 1. Ricour, C. et al. (2009) The Journal of general virology 90, 177-86. PMID: 19088287 2. Sorgeloos, F. et al. (2013) PLoS pathogens 9, e1003474. PMID: 23825954 3. Drappier, M. et al. (2018) PLoS pathogens 14, e1006989. PMID: 29652922 | ||||||||
| 注意事項 | For research use only. |
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