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Anti-TNKS2 Polyclonal Antibody (HV525014)

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Vista general
Número de catálogoHV525014
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human TNKS2 (Ser959-Gly1166).
Objetivo TANK2, ADP-ribosyltransferase diphtheria toxin-like 6, Tankyrase-like protein, Poly [ADP-ribose] polymerase tankyrase-2, Tankyrase-related protein, TNKS2, Tankyrase II, ARTD6, Poly [ADP-ribose] polymerase 5B, Tankyrase-2, PARP5B, TNKL, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, TNKS-2, Protein poly-ADP-ribosyltransferase tankyrase-2
Purificación Purified by antigen affinity column.
Número de acceso Q9H2K2
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) is a ~126 kDa protein. Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.

1. Cook, BD. et al. (2002) Molecular and cellular biology 22, 332-42. PMID: 11739745
2. Sbodio, JI. et al. (2002) The Biochemical journal 361, 451-9. PMID: 11802774
3. Huang, SM. et al. (2009) Nature 461, 614-20. PMID: 19759537
4. Zhang, Y. et al. (2011) Nature cell biology 13, 623-9. PMID: 21478859
5. Cho-Park, PF. et al. (2013) Cell 153, 614-27. PMID: 23622245
6. Vyas, S. et al. (2014) Nature communications 5, 4426. PMID: 25043379
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-TNKS2 Polyclonal Antibody

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