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| カタログ番号 | HV525014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TNKS2 (Ser959-Gly1166). | ||||||||
| ターゲット | TANK2, ADP-ribosyltransferase diphtheria toxin-like 6, Tankyrase-like protein, Poly [ADP-ribose] polymerase tankyrase-2, Tankyrase-related protein, TNKS2, Tankyrase II, ARTD6, Poly [ADP-ribose] polymerase 5B, Tankyrase-2, PARP5B, TNKL, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, TNKS-2, Protein poly-ADP-ribosyltransferase tankyrase-2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H2K2 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) is a ~126 kDa protein. Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity. 1. Cook, BD. et al. (2002) Molecular and cellular biology 22, 332-42. PMID: 11739745 2. Sbodio, JI. et al. (2002) The Biochemical journal 361, 451-9. PMID: 11802774 3. Huang, SM. et al. (2009) Nature 461, 614-20. PMID: 19759537 4. Zhang, Y. et al. (2011) Nature cell biology 13, 623-9. PMID: 21478859 5. Cho-Park, PF. et al. (2013) Cell 153, 614-27. PMID: 23622245 6. Vyas, S. et al. (2014) Nature communications 5, 4426. PMID: 25043379 | ||||||||
| 注意事項 | For research use only. |
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