

| Numéro de catalogue | HV619014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-TOLLIP Polyclonal Antibody (HV619014) is a rabbit polyclonal antibody detecting TOLLIP in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human TOLLIP (Gln28-Asp261). | ||||||||
| Cible | Toll-interacting protein, TOLLIP | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q9H0E2 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Toll-interacting protein (TOLLIP) is a ~30 kDa protein. Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. 1. Burns, K. et al. (2000) Nature cell biology 2, 346-51. PMID: 10854325 2. Zhang, G. et al. (2002) The Journal of biological chemistry 277, 7059-65. PMID: 11751856 3. Lu, K. et al. (2014) Cell 158, 549-63. PMID: 25042851 4. Katoh, Y. et al. (2004) The Journal of biological chemistry 279, 24435-43. PMID: 15047686 5. Xiao, S. et al. (2015) Structure (London, England : 1993) 23, 1910-1920. PMID: 26320582 | ||||||||
| Note | For research use only. |
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