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| カタログ番号 | HV619014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TOLLIP Polyclonal Antibody (HV619014) is a rabbit polyclonal antibody detecting TOLLIP in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TOLLIP (Gln28-Asp261). | ||||||||
| ターゲット | Toll-interacting protein, TOLLIP | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H0E2 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Toll-interacting protein (TOLLIP) is a ~30 kDa protein. Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. 1. Burns, K. et al. (2000) Nature cell biology 2, 346-51. PMID: 10854325 2. Zhang, G. et al. (2002) The Journal of biological chemistry 277, 7059-65. PMID: 11751856 3. Lu, K. et al. (2014) Cell 158, 549-63. PMID: 25042851 4. Katoh, Y. et al. (2004) The Journal of biological chemistry 279, 24435-43. PMID: 15047686 5. Xiao, S. et al. (2015) Structure (London, England : 1993) 23, 1910-1920. PMID: 26320582 | ||||||||
| 注意事項 | For research use only. |
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