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| カタログ番号 | HF720014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TOMM40 Polyclonal Antibody (HF720014) is a rabbit polyclonal antibody detecting TOMM40 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TOMM40 (Met1-Gly361). | ||||||||
| ターゲット | PEREC1, TOM40, TOMM40, Mitochondrial import receptor subunit TOM40 homolog, C19orf1, p38.5, Protein Haymaker, Translocase of outer membrane 40 kDa subunit homolog | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O96008 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Mitochondrial import receptor subunit TOM40 homolog (TOMM40) is a ~37 kDa protein. Channel-forming protein that forms part of the translocase of the outer mitochondrial membrane (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria. 1. Humphries, AD. et al. (2005) The Journal of biological chemistry 280, 11535-43. PMID: 15644312 2. Namba, T. (2019) Science advances 5, eaaw1386. PMID: 31206022 3. Callegari, S. et al. (2025) Science (New York, N.Y.) 388, 303-310. PMID: 40080546 | ||||||||
| 注意事項 | For research use only. |
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