

| Каталожный номер | HF720014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-TOMM40 Polyclonal Antibody (HF720014) is a rabbit polyclonal antibody detecting TOMM40 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human TOMM40 (Met1-Gly361). | ||||||||
| Цель | PEREC1, TOM40, TOMM40, Mitochondrial import receptor subunit TOM40 homolog, C19orf1, p38.5, Protein Haymaker, Translocase of outer membrane 40 kDa subunit homolog | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O96008 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Mitochondrial import receptor subunit TOM40 homolog (TOMM40) is a ~37 kDa protein. Channel-forming protein that forms part of the translocase of the outer mitochondrial membrane (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria. 1. Humphries, AD. et al. (2005) The Journal of biological chemistry 280, 11535-43. PMID: 15644312 2. Namba, T. (2019) Science advances 5, eaaw1386. PMID: 31206022 3. Callegari, S. et al. (2025) Science (New York, N.Y.) 388, 303-310. PMID: 40080546 | ||||||||
| Примечание | For research use only. |
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