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| カタログ番号 | HC342014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TP53BP1 Polyclonal Antibody (HC342014) is a rabbit polyclonal antibody detecting TP53BP1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TP53BP1 (Ala1614-His1972). | ||||||||
| ターゲット | TP53-binding protein 1, TP53BP1, p53-binding protein 1, p53BP1, 53BP1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q12888 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | TP53-binding protein 1 (TP53BP1) is a ~213 kDa protein. Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs. 1. Wang, B. et al. (2002) Science (New York, N.Y.) 298, 1435-8. PMID: 12364621 2. Botuyan, MV. et al. (2006) Cell 127, 1361-73. PMID: 17190600 3. Kang, Y. et al. (2011) Biochemical and biophysical research communications 404, 476-81. PMID: 21144835 4. Chapman, JR. et al. (2012) Journal of cell science 125, 3529-34. PMID: 22553214 5. Escribano-Díaz, C. et al. (2013) Molecular cell 49, 872-83. PMID: 23333306 6. Jacquet, K. et al. (2016) Molecular cell 62, 409-421. PMID: 27153538 7. Drané, P. et al. (2017) Nature 543, 211-216. PMID: 28241136 8. Bigot, N. et al. (2019) eLife 8. PMID: 31135337 9. Swift, ML. et al. (2023) Nature structural & molecular biology 30, 1456-1467. PMID: 37696958 | ||||||||
| 注意事項 | For research use only. |
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