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| カタログ番号 | HW491014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TPMT Polyclonal Antibody (HW491014) is a rabbit polyclonal antibody detecting TPMT in ELISA, IHC, WB. Suitable for Human, Pan troglodytes, and Pongo pygmaeus.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TPMT (Leu26-His227). | ||||||||
| ターゲット | Thiopurine methyltransferase, Thiopurine S-methyltransferase, TPMT | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P51580 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Thiopurine S-methyltransferase (TPMT) is a ~28 kDa protein. Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. 1. Peng, Y. et al. (2008) Biochemistry 47, 6216-25. PMID: 18484748 2. Weinshilboum, RM. et al. (1978) Clinica chimica acta; international journal of clinical chemistry 85, 323-33. PMID: 657528 | ||||||||
| 注意事項 | For research use only. |
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