Anti-TPPP Polyclonal Antibody (HF892014)

Name: Anti-TPPP Polyclonal Antibody
Brand: abinScience
SKU: HF892014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Número de catálogo

HF892014

Descripción

Anti-TPPP Polyclonal Antibody (HF892014) is a rabbit polyclonal antibody detecting TPPP in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human TPPP (Ala8-Thr210).

Objetivo

25 kDa brain-specific protein, TPPP/p25, Tubulin polymerization-promoting protein, p24, p25-alpha, TPPP, TPPP1

Purificación

Purified by antigen affinity column.

Número de acceso

O94811

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Tubulin polymerization-promoting protein (TPPP) is a ~23 kDa protein. Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear. In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network.

1. Fu, MM. et al. (2019) Cell 179, 132-146.e14. PMID: 31522887

2. Doi, S. et al. (2021) Cell calcium 96, 102404. PMID: 33831707

3. Zotter, A. et al. (2011) FEBS letters 585, 803-8. PMID: 21316364

4. Zotter, Á. et al. (2011) Biochemistry 50, 9568-78. PMID: 21995432

5. Vincze, O. et al. (2006) Biochemistry 45, 13818-26. PMID: 17105200

6. Hlavanda, E. et al. (2007) The Journal of biological chemistry 282, 29531-9. PMID: 17693641

7. Acevedo, K. et al. (2007) Experimental cell research 313, 4091-106. PMID: 18028908

8. DeBonis, S. et al. (2015) Scientific reports 5, 13242. PMID: 26289831

9. Tokési, N. et al. (2010) The Journal of biological chemistry 285, 17896-906. PMID: 20308065

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-TPPP Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-TPPP Polyclonal Antibody (HF892014)

Vista general

Imágenes

Referencias

Datasheet

SDS