Anti-TPPP Polyclonal Antibody (HF892014)

Name: Anti-TPPP Polyclonal Antibody
Brand: abinScience
SKU: HF892014
Price: 168 USD
Availability: InStock

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100ug

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SDS

Aperçu

Numéro de catalogue

HF892014

Description

Anti-TPPP Polyclonal Antibody (HF892014) is a rabbit polyclonal antibody detecting TPPP in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human TPPP (Ala8-Thr210).

Cible

25 kDa brain-specific protein, TPPP/p25, Tubulin polymerization-promoting protein, p24, p25-alpha, TPPP, TPPP1

Purification

Purified by antigen affinity column.

Numéro d'accès

O94811

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Tubulin polymerization-promoting protein (TPPP) is a ~23 kDa protein. Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear. In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network.

1. Fu, MM. et al. (2019) Cell 179, 132-146.e14. PMID: 31522887

2. Doi, S. et al. (2021) Cell calcium 96, 102404. PMID: 33831707

3. Zotter, A. et al. (2011) FEBS letters 585, 803-8. PMID: 21316364

4. Zotter, Á. et al. (2011) Biochemistry 50, 9568-78. PMID: 21995432

5. Vincze, O. et al. (2006) Biochemistry 45, 13818-26. PMID: 17105200

6. Hlavanda, E. et al. (2007) The Journal of biological chemistry 282, 29531-9. PMID: 17693641

7. Acevedo, K. et al. (2007) Experimental cell research 313, 4091-106. PMID: 18028908

8. DeBonis, S. et al. (2015) Scientific reports 5, 13242. PMID: 26289831

9. Tokési, N. et al. (2010) The Journal of biological chemistry 285, 17896-906. PMID: 20308065

Note

For research use only.

Images

Reférences

Fiche technique

Anti-TPPP Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-TPPP Polyclonal Antibody (HF892014)

Aperçu

Images

Reférences

Fiche technique

SDS