Anti-TPPP Polyclonal Antibody (HF892014)

Name: Anti-TPPP Polyclonal Antibody
Brand: abinScience
SKU: HF892014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HF892014

Описание

Anti-TPPP Polyclonal Antibody (HF892014) is a rabbit polyclonal antibody detecting TPPP in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human TPPP (Ala8-Thr210).

Цель

25 kDa brain-specific protein, TPPP/p25, Tubulin polymerization-promoting protein, p24, p25-alpha, TPPP, TPPP1

Очистка

Purified by antigen affinity column.

Номер доступа

O94811

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Tubulin polymerization-promoting protein (TPPP) is a ~23 kDa protein. Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear. In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network.

1. Fu, MM. et al. (2019) Cell 179, 132-146.e14. PMID: 31522887

2. Doi, S. et al. (2021) Cell calcium 96, 102404. PMID: 33831707

3. Zotter, A. et al. (2011) FEBS letters 585, 803-8. PMID: 21316364

4. Zotter, Á. et al. (2011) Biochemistry 50, 9568-78. PMID: 21995432

5. Vincze, O. et al. (2006) Biochemistry 45, 13818-26. PMID: 17105200

6. Hlavanda, E. et al. (2007) The Journal of biological chemistry 282, 29531-9. PMID: 17693641

7. Acevedo, K. et al. (2007) Experimental cell research 313, 4091-106. PMID: 18028908

8. DeBonis, S. et al. (2015) Scientific reports 5, 13242. PMID: 26289831

9. Tokési, N. et al. (2010) The Journal of biological chemistry 285, 17896-906. PMID: 20308065

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-TPPP Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-TPPP Polyclonal Antibody (HF892014)

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