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| カタログ番号 | HS785014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TRADD Polyclonal Antibody (HS785014) is a rabbit polyclonal antibody detecting TRADD in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TRADD (Met61-Leu297). | ||||||||
| ターゲット | TRADD, TNFR1-associated DEATH domain protein, Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFRSF1A-associated via death domain | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15628 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) is a ~34 kDa protein. Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. 1. Li, S. et al. (2013) Nature 501, 242-6. PMID: 23955153 2. Hsu, H. et al. (1995) Cell 81, 495-504. PMID: 7758105 3. Hsu, H. et al. (1996) Immunity 4, 387-96. PMID: 8612133 | ||||||||
| 注意事項 | For research use only. |
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