Anti-TREM2 Recombinant Antibody (EOS006215) (HV166063)

Name: Anti-TREM2 Recombinant Antibody (EOS006215)
Brand: abinScience
SKU: HV166063
Price: 191 USD
Availability: InStock

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Prix(USD) :

Spécification :

50ug
100ug
1mg

Nombre :

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HV166063

Reactivité des espèces

Human

Applications

ELISA, FACS, Functional assay

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

IgG1, kappa

ID de clone

EOS006215

Cible

Triggering receptor expressed on myeloid cells 2, TREM-2, Triggering receptor expressed on monocytes 2, TREM2

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q9NZC2

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Triggering receptor expressed on myeloid cells 2 (TREM2) is a ~25 kDa protein. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin.

1. Bouchon, A. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 4991-5. PMID: 10799849

2. Yeh, FL. et al. (2016) Neuron 91, 328-40. PMID: 27477018

3. Zhao, Y. et al. (2018) Neuron 97, 1023-1031.e7. PMID: 29518356

4. Sudom, A. et al. (2018) The Journal of biological chemistry 293, 12634-12646. PMID: 29794134

5. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 24990881

6. Filipello, F. et al. (2018) Immunity 48, 979-991.e8. PMID: 29752066

7. Bouchon, A. et al. (2001) The Journal of experimental medicine 194, 1111-22. PMID: 11602640

8. Paloneva, J. et al. (2003) The Journal of experimental medicine 198, 669-75. PMID: 12925681

Note

For research use only

Isotype Control

Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)