中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HF525014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TRPA1 (Asp63-Ile370). | ||||||||
| ターゲット | Transformation-sensitive protein p120, TRPA1, Transient receptor potential cation channel subfamily A member 1, Ankyrin-like with transmembrane domains protein 1, ANKTM1, Wasabi receptor | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75762 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Transient receptor potential cation channel subfamily A member 1 (TRPA1) is a ~127 kDa protein. Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function. Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization. Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner. 1. Zurborg, S. et al. (2007) Nature neuroscience 10, 277-9. PMID: 17259981 2. Bobkov, YV. et al. (2011) Biochimica et biophysica acta 1808, 1120-8. PMID: 21195050 3. Takahashi, N. et al. (2011) Nature chemical biology 7, 701-11. PMID: 21873995 4. Buday, T. et al. (2012) Cough (London, England) 8, 11. PMID: 23199233 5. Moparthi, L. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 16901-6. PMID: 25389312 6. Liu, C. et al. (2021) Neuron 109, 273-284.e4. PMID: 33152265 7. Hu, H. et al. (2009) Nature chemical biology 5, 183-90. PMID: 19202543 8. Kremeyer, B. et al. (2010) Neuron 66, 671-80. PMID: 20547126 | ||||||||
| 注意事項 | For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
