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| カタログ番号 | HC206014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TRPV4 Polyclonal Antibody (HC206014) is a rabbit polyclonal antibody detecting TRPV4. Suitable for Human, Rat, and Mouse.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant TRPV4 (Arg151-Asn361). | ||||||||
| ターゲット | OTRPC4, Osm-9-like TRP channel 4, TRP12, TRPV4, Transient receptor potential cation channel subfamily V member 4, Transient receptor potential protein 12, TrpV4, VR-OAC, VRL-2, VRL2, VROAC, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, Vanilloid receptor-related osmotically-activated channel | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 観測分子量 | 100 kDa | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9HBA0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||||||
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. | ||||||||
| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Transient receptor potential cation channel subfamily V member 4 (TRPV4) is a ~98 kDa protein. Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. 1. Arniges, M. et al. (2006) The Journal of biological chemistry 281, 1580-6. PMID: 16293632 2. Köttgen, M. et al. (2008) The Journal of cell biology 182, 437-47. PMID: 18695040 3. Garcia-Elias, A. et al. (2008) The Journal of biological chemistry 283, 31284-8. PMID: 18826956 4. Fiorillo, C. et al. (2012) Neurogenetics 13, 195-203. PMID: 22526352 5. Thorneloe, KS. et al. (2012) Science translational medicine 4, 159ra148. PMID: 23136043 6. Doñate-Macián, P. et al. (2018) Nature communications 9, 2307. PMID: 29899501 | ||||||||
| 注意事項 | For research use only |
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