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Anti-TTK Polyclonal Antibody (HW490014)

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Aperçu
Numéro de catalogueHW490014
Description
Anti-TTK Polyclonal Antibody (HW490014) is a rabbit polyclonal antibody detecting TTK in ELISA, IHC, WB. Suitable for Human, Macaca fascicularis, and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human TTK (Gly532-Ala787).
Cible Dual specificity protein kinase TTK, MPS1L1, Phosphotyrosine picked threonine-protein kinase, TTK, PYT, MPS1
Purification Purified by antigen affinity column.
Numéro d'accès P33981
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Dual specificity protein kinase TTK is a ~97 kDa protein. Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates.

1. Jelluma, N. et al. (2008) Cell 132, 233-46. PMID: 18243099
2. Maciejowski, J. et al. (2017) Developmental cell 41, 143-156.e6. PMID: 28441529
3. Ji, W. et al. (2018) The Journal of biological chemistry 293, 484-496. PMID: 29162720
4. Yang, H. et al. (2019) Molecular biology of the cell 30, 1060-1068. PMID: 30785839
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-TTK Polyclonal Antibody

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