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| カタログ番号 | HW490014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TTK Polyclonal Antibody (HW490014) is a rabbit polyclonal antibody detecting TTK in ELISA, IHC, WB. Suitable for Human, Macaca fascicularis, and Mouse.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TTK (Gly532-Ala787). | ||||||||
| ターゲット | Dual specificity protein kinase TTK, MPS1L1, Phosphotyrosine picked threonine-protein kinase, TTK, PYT, MPS1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P33981 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Dual specificity protein kinase TTK is a ~97 kDa protein. Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates. 1. Jelluma, N. et al. (2008) Cell 132, 233-46. PMID: 18243099 2. Maciejowski, J. et al. (2017) Developmental cell 41, 143-156.e6. PMID: 28441529 3. Ji, W. et al. (2018) The Journal of biological chemistry 293, 484-496. PMID: 29162720 4. Yang, H. et al. (2019) Molecular biology of the cell 30, 1060-1068. PMID: 30785839 | ||||||||
| 注意事項 | For research use only. |
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