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Anti-UBE2A Polyclonal Antibody (HB413014)

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Anti-UBE2A Polyclonal Antibody
Anti-UBE2A Polyclonal Antibody
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Vista general
Número de catálogoHB413014
Descripción
Anti-UBE2A Polyclonal Antibody (HB413014) is a rabbit polyclonal antibody detecting Ubiquitin-conjugating enzyme E2 A; 2.3.2.23; E2 ubiquitin-conjugating enzyme A; RAD6 homolog A; HR6A; hHR6A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A; UBE2A; RAD6A in ELISA, IHC, WB. Suitable for Human, Mouse, Rabbit, Rat, and Bovine.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant human UBE2A (Met1-Cys152).
Objetivo Ubiquitin-conjugating enzyme E2 A; 2.3.2.23; E2 ubiquitin-conjugating enzyme A; RAD6 homolog A; HR6A; hHR6A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A; UBE2A; RAD6A
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P49459, Q9Z255, P63146, P63148, P63149, P63147, Q32P99, P25153, P52478
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Ubiquitin-conjugating enzyme E2 A (UBE2A) is a ~17 kDa protein. E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Together with the E3 enzyme BRE1 (RNF20 and/or RNF40), plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Involved in mitophagy by acting as a E2 ubiquitin-conjugating enzyme for PRKN.

1. Kim, J. et al. (2005) Molecular cell 20, 759-70. PMID: 16337599
2. David, Y. et al. (2010) The Journal of biological chemistry 285, 8595-604. PMID: 20061386
3. Haddad, DM. et al. (2013) Molecular cell 50, 831-43. PMID: 23685073
4. Hong, JH. et al. (2015) Molecular & cellular proteomics : MCP 14, 674-85. PMID: 25582440
5. Haakonsen, DL. et al. (2024) Nature 626, 874-880. PMID: 38297121
6. Barnsby-Greer, L. et al. (2024) Nature structural & molecular biology 31, 351-363. PMID: 38182926
Nota For research use only
Imágenes
  • Anti-UBE2A Polyclonal Antibody

    Western blot

    Western blot analysis was performed using anti-UBE2A polyclonal antibody at 1ug/mL on various samples.
    Lane 1: Hela cell lysate
    Lane 2: A549 cell lysate
    Lane 3: 293T cell lysate
    Lane 4: A375 cell lysate
    Lane 5: SW620 cell lysate
    Lane 6: Jurkat cell lysate
    Lane 7: N2A cell lysate
    Lane 8: NIH3T3 cell lysate
    Lane 9: Mouse brain lysate
    Lane 10: Rat brain lysate

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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