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| カタログ番号 | HX198014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human UBE2L3 (Ser4-Asp154). | ||||||||
| ターゲット | UBE2L3, Ubiquitin-conjugating enzyme E2-F1, UBCH7, Ubiquitin-conjugating enzyme E2 L3, UBCE7, L-UBC, E2 ubiquitin-conjugating enzyme L3, UbcH7, Ubiquitin-protein ligase L3, Ubiquitin carrier protein L3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P68036 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) is a ~17 kDa protein. Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine; in contrast, it has activity with the RBR family E3 enzymes, such as PRKN, RNF31 and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates ubiquitination by the CUL9-RBX1 complex. In vitro catalyzes 'Lys-11'-linked polyubiquitination. 1. Horn-Ghetko, D. et al. (2024) Nature structural & molecular biology 31, 1083-1094. PMID: 38605244 | ||||||||
| 注意事項 | For research use only. |
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