中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HB024014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-UCP1 Polyclonal Antibody (HB024014) is a rabbit polyclonal antibody detecting UCP1 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human UCP1 (Met1-Thr307). | ||||||||
| ターゲット | Solute carrier family 25 member 7, UCP1, SLC25A7, Mitochondrial brown fat uncoupling protein 1, Thermogenin, UCP, UCP 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P25874 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Mitochondrial brown fat uncoupling protein 1 (UCP1) is a ~33 kDa protein. Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria. 1. Hoang, T. et al. (2013) The Journal of biological chemistry 288, 36244-58. PMID: 24196960 2. Zhao, L. et al. (2017) Structure (London, England : 1993) 25, 1371-1379.e3. PMID: 28781081 | ||||||||
| 注意事項 | For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
