Please ensure Javascript is enabled for purposes of website accessibility
Contactez-nous Contactez-nous
FR
Accueil > Products > Anticorps > Anticorps Primaires

Anti-USP12 Polyclonal Antibody (HB585014)

Fiche technique Partager le produit Copier les informations
Prix(USD) : --
Spécification :
  • 50ug
  • 100ug
Nombre :
Contactez-nous

  • Aperçu

  • Images

  • Reférences

  • Fiche technique

  • SDS

Aperçu
Numéro de catalogueHB585014
Description
Anti-USP12 Polyclonal Antibody (HB585014) is a rabbit polyclonal antibody detecting Ubiquitin carboxyl-terminal hydrolase 12; 3.4.19.12; Deubiquitinating enzyme 12; Ubiquitin thioesterase 12; Ubiquitin-hydrolyzing enzyme 1; Ubiquitin-specific-processing protease 12; USP12; UBH1; USP12L1 in ELISA, IHC, WB. Suitable for Human, Frog, Bovine, Mouse, and Zebrafish.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant human USP12 (Ala20-Asp370).
Cible Ubiquitin carboxyl-terminal hydrolase 12; 3.4.19.12; Deubiquitinating enzyme 12; Ubiquitin thioesterase 12; Ubiquitin-hydrolyzing enzyme 1; Ubiquitin-specific-processing protease 12; USP12; UBH1; USP12L1
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès O75317, Q52KZ6, Q5M981, A5D9H7, Q9D9M2, A4FUN7, F1M625, P62068, A5WWB0, P62069
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Ubiquitin carboxyl-terminal hydrolase 12 (USP12) is a ~42 kDa protein. Deubiquitinating enzyme that plays various roles in the regulation of the immune response and inflammation. During TCR engagement and activation, translocates into the cytoplasm and deubiquitinates its substrates LAT and TRAT1 and prevents their lysosome-dependent degradation to stabilize the TCR signaling complex at the plasma membrane. Plays an essential role in the selective LPS-induced macrophage response through the activation of NF-kappa-B pathway. In addition, promotes that antiviral immune response through targeting DNA sensor IFI16 to inhibit its proteasome-dependent degradation. Participates in the interferon signaling pathway and antiviral response independently of its deubiquitinase activity by maintaining nuclear phosphorylated STAT1 levels via inhibition of its CREBBP-mediated acetylation and subsequent dephosphorylation.

1. Cohn, MA. et al. (2009) The Journal of biological chemistry 284, 5343-51. PMID: 19075014
2. Li, H. et al. (2016) Molecular cell 63, 249-260. PMID: 27373336
3. Jahan, AS. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E705-14. PMID: 26811477
4. Nayak, TKS. et al. (2017) Biochemical and biophysical research communications 483, 69-74. PMID: 28063927
5. Fu, Y. et al. (2023) PLoS pathogens 19, e1011480. PMID: 37410794
6. Liu, J. et al. (2020) PLoS pathogens 16, e1008215. PMID: 31899788
7. Choi, HS. et al. (2022) International journal of molecular sciences 23. PMID: 36361894
8. Moretti, J. et al. (2012) The Journal of biological chemistry 287, 29429-41. PMID: 22778262
9. Aron, R. et al. (2018) Nature communications 9, 3191. PMID: 30266909
10. Gangula, NR. et al. (2013) The Journal of biological chemistry 288, 34545-54. PMID: 24145035
Note For research use only
Images
Reférences
Fiche technique
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Recommandation

Contactez-nous pour les devis personnalisés, les demandes en gros et tout autre problème.

Courrier : [email protected]

Liste des distributeurs

Obtenir un devis gratuit
Anti-USP12 Polyclonal Antibody

Accès rapide

Contactez-nous

  • +86-027-65523339

  • [email protected]

  • Bâtiment C, No. 666, Rue Shendunsi, Wuhan, 430206, Chine

  • linkedin
  • Ins
  • youtube
  • youtube
Droit d'auteur © 2026 abinScience. Tous droits réservés. Tous les produits sont uniquement à usage de recherche