Anti-USP25 Polyclonal Antibody (HV501014)

Name: Anti-USP25 Polyclonal Antibody
Brand: abinScience
SKU: HV501014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Número de catálogo

HV501014

Descripción

Anti-USP25 Polyclonal Antibody (HV501014) is a rabbit polyclonal antibody detecting USP25 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human USP25 (Glu862-Arg1055).

Objetivo

Ubiquitin-specific-processing protease 25, Ubiquitin thioesterase 25, USP21, USP on chromosome 21, Ubiquitin carboxyl-terminal hydrolase 25, Deubiquitinating enzyme 25, USP25

Purificación

Purified by antigen affinity column.

Número de acceso

Q9UHP3

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Ubiquitin carboxyl-terminal hydrolase 25 (USP25) is a ~122 kDa protein. Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response. Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2. Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program. Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2. In turn, restricts virus production by regulating cholesterol biosynthetic flux.

1. Qian, G. et al. (2018) Biochemical and biophysical research communications 498, 537-543. PMID: 29518389

2. Teo, QW. et al. (2023) Developmental cell 58, 2495-2509.e6. PMID: 37683630

3. Xu, D. et al. (2017) Genes & development 31, 1024-1035. PMID: 28619731

4. Sauer, F. et al. (2019) Molecular cell 74, 421-435.e10. PMID: 30926243

5. Fan, CX. et al. (2024) Brain : a journal of neurology 147, 3442-3457. PMID: 38875478

6. Cai, C. et al. (2023) Nature communications 14, 3648. PMID: 37339955

7. Zhong, B. et al. (2012) Nature immunology 13, 1110-7. PMID: 23042150

8. Wen, J. et al. (2019) Molecular immunology 106, 53-62. PMID: 30579117

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-USP25 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-USP25 Polyclonal Antibody (HV501014)

Vista general

Imágenes

Referencias

Datasheet

SDS