Anti-USP25 Polyclonal Antibody (HV501014)

Name: Anti-USP25 Polyclonal Antibody
Brand: abinScience
SKU: HV501014
Price: 168 USD
Availability: InStock

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50ug
100ug

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SDS

Aperçu

Numéro de catalogue

HV501014

Description

Anti-USP25 Polyclonal Antibody (HV501014) is a rabbit polyclonal antibody detecting USP25 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human USP25 (Glu862-Arg1055).

Cible

Ubiquitin-specific-processing protease 25, Ubiquitin thioesterase 25, USP21, USP on chromosome 21, Ubiquitin carboxyl-terminal hydrolase 25, Deubiquitinating enzyme 25, USP25

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9UHP3

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Ubiquitin carboxyl-terminal hydrolase 25 (USP25) is a ~122 kDa protein. Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response. Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2. Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program. Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2. In turn, restricts virus production by regulating cholesterol biosynthetic flux.

1. Qian, G. et al. (2018) Biochemical and biophysical research communications 498, 537-543. PMID: 29518389

2. Teo, QW. et al. (2023) Developmental cell 58, 2495-2509.e6. PMID: 37683630

3. Xu, D. et al. (2017) Genes & development 31, 1024-1035. PMID: 28619731

4. Sauer, F. et al. (2019) Molecular cell 74, 421-435.e10. PMID: 30926243

5. Fan, CX. et al. (2024) Brain : a journal of neurology 147, 3442-3457. PMID: 38875478

6. Cai, C. et al. (2023) Nature communications 14, 3648. PMID: 37339955

7. Zhong, B. et al. (2012) Nature immunology 13, 1110-7. PMID: 23042150

8. Wen, J. et al. (2019) Molecular immunology 106, 53-62. PMID: 30579117

Note

For research use only.

Images

Reférences

Fiche technique

Anti-USP25 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-USP25 Polyclonal Antibody (HV501014)

Aperçu

Images

Reférences

Fiche technique

SDS