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| カタログ番号 | HV501014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-USP25 Polyclonal Antibody (HV501014) is a rabbit polyclonal antibody detecting USP25 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human USP25 (Glu862-Arg1055). | ||||||||
| ターゲット | Ubiquitin-specific-processing protease 25, Ubiquitin thioesterase 25, USP21, USP on chromosome 21, Ubiquitin carboxyl-terminal hydrolase 25, Deubiquitinating enzyme 25, USP25 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UHP3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin carboxyl-terminal hydrolase 25 (USP25) is a ~122 kDa protein. Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response. Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2. Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program. Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2. In turn, restricts virus production by regulating cholesterol biosynthetic flux. 1. Qian, G. et al. (2018) Biochemical and biophysical research communications 498, 537-543. PMID: 29518389 2. Teo, QW. et al. (2023) Developmental cell 58, 2495-2509.e6. PMID: 37683630 3. Xu, D. et al. (2017) Genes & development 31, 1024-1035. PMID: 28619731 4. Sauer, F. et al. (2019) Molecular cell 74, 421-435.e10. PMID: 30926243 5. Fan, CX. et al. (2024) Brain : a journal of neurology 147, 3442-3457. PMID: 38875478 6. Cai, C. et al. (2023) Nature communications 14, 3648. PMID: 37339955 7. Zhong, B. et al. (2012) Nature immunology 13, 1110-7. PMID: 23042150 8. Wen, J. et al. (2019) Molecular immunology 106, 53-62. PMID: 30579117 | ||||||||
| 注意事項 | For research use only. |
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