Anti-USP25 Polyclonal Antibody (HV501014)

Name: Anti-USP25 Polyclonal Antibody
Brand: abinScience
SKU: HV501014
Price: 168 USD
Availability: InStock

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Каталожный номер

HV501014

Описание

Anti-USP25 Polyclonal Antibody (HV501014) is a rabbit polyclonal antibody detecting USP25 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human USP25 (Glu862-Arg1055).

Цель

Ubiquitin-specific-processing protease 25, Ubiquitin thioesterase 25, USP21, USP on chromosome 21, Ubiquitin carboxyl-terminal hydrolase 25, Deubiquitinating enzyme 25, USP25

Очистка

Purified by antigen affinity column.

Номер доступа

Q9UHP3

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Ubiquitin carboxyl-terminal hydrolase 25 (USP25) is a ~122 kDa protein. Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response. Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2. Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program. Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2. In turn, restricts virus production by regulating cholesterol biosynthetic flux.

1. Qian, G. et al. (2018) Biochemical and biophysical research communications 498, 537-543. PMID: 29518389

2. Teo, QW. et al. (2023) Developmental cell 58, 2495-2509.e6. PMID: 37683630

3. Xu, D. et al. (2017) Genes & development 31, 1024-1035. PMID: 28619731

4. Sauer, F. et al. (2019) Molecular cell 74, 421-435.e10. PMID: 30926243

5. Fan, CX. et al. (2024) Brain : a journal of neurology 147, 3442-3457. PMID: 38875478

6. Cai, C. et al. (2023) Nature communications 14, 3648. PMID: 37339955

7. Zhong, B. et al. (2012) Nature immunology 13, 1110-7. PMID: 23042150

8. Wen, J. et al. (2019) Molecular immunology 106, 53-62. PMID: 30579117

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-USP25 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-USP25 Polyclonal Antibody (HV501014)

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