Anti-VDR Polyclonal Antibody (HY304014)

Name: Anti-VDR Polyclonal Antibody
Brand: abinScience
SKU: HY304014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HY304014

Reactivité des espèces

Human, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human VDR (Met272-Ser427).

Cible

VDR, Vitamin D3 receptor, 1, 25-dihydroxyvitamin D3 receptor, NR1I1, Nuclear receptor subfamily 1 group I member 1

Purification

Purified by antigen affinity column.

Numéro d'accès

P11473

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Vitamin D3 receptor (VDR) is a ~48 kDa protein. Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites.

1. Rochel, N. et al. (2000) Molecular cell 5, 173-9. PMID: 10678179

2. Eelen, G. et al. (2005) Molecular pharmacology 67, 1566-73. PMID: 15728261

3. Hourai, S. et al. (2006) Journal of medicinal chemistry 49, 5199-205. PMID: 16913708

4. Tamura, M. et al. (2017) Scientific reports 7, 5102. PMID: 28698609

5. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846

6. Makishima, M. et al. (2002) Science (New York, N.Y.) 296, 1313-6. PMID: 12016314

7. Hashimoto, N. et al. (2020) Kidney international 97, 1164-1180. PMID: 32354638

Note

For research use only.

Images

Reférences

Fiche technique

Anti-VDR Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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