Anti-WDR82 Polyclonal Antibody (HB354014)

Name: Anti-WDR82 Polyclonal Antibody
Brand: abinScience
SKU: HB354014
Price: 168 USD
Availability: InStock

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50ug
100ug

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SDS

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Numéro de catalogue

HB354014

Description

Anti-WDR82 Polyclonal Antibody (HB354014) is a rabbit polyclonal antibody detecting WD repeat-containing protein 82; WDR82; SWD2; TMEM113; WDR82A; UNQ9342/PRO34047 in ELISA, IHC, WB. Suitable for Human, Mouse, Chicken, Frog, and Zebrafish.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant human WDR82 (Met1-Asp313).

Cible

WD repeat-containing protein 82; WDR82; SWD2; TMEM113; WDR82A; UNQ9342/PRO34047

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q6UXN9, Q8BFQ4, Q5ZMV7, Q58E77, Q640J6, Q6NV31

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

WD repeat-containing protein 82 (WDR82) is a ~35 kDa protein. Regulatory component of the SET1/COMPASS complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation. PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs).

1. Lee, JH. et al. (2008) Molecular and cellular biology 28, 609-18. PMID: 17998332

2. Wu, M. et al. (2008) Molecular and cellular biology 28, 7337-44. PMID: 18838538

3. Lee, JH. et al. (2010) The Journal of biological chemistry 285, 24466-76. PMID: 20516061

4. Wang, Z. et al. (2024) Molecular cell 84, 4824-4842.e7. PMID: 39603240

5. Kelley, JR. et al. (2024) Molecular cell 84, 4843-4861.e8. PMID: 39603239

6. Austenaa, LMI. et al. (2021) Nature structural & molecular biology 28, 337-346. PMID: 33767452

7. Estell, C. et al. (2021) eLife 10. PMID: 33913806

Note

For research use only

Images

Reférences

Fiche technique

Anti-WDR82 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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Kits d'Essai

Anti-WDR82 Polyclonal Antibody (HB354014)

Aperçu

Images

Reférences

Fiche technique

SDS