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| カタログ番号 | HB354014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-WDR82 Polyclonal Antibody (HB354014) is a rabbit polyclonal antibody detecting WD repeat-containing protein 82; WDR82; SWD2; TMEM113; WDR82A; UNQ9342/PRO34047 in ELISA, IHC, WB. Suitable for Human, Mouse, Chicken, Frog, and Zebrafish.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human WDR82 (Met1-Asp313). | ||||||||
| ターゲット | WD repeat-containing protein 82; WDR82; SWD2; TMEM113; WDR82A; UNQ9342/PRO34047 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6UXN9, Q8BFQ4, Q5ZMV7, Q58E77, Q640J6, Q6NV31 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | WD repeat-containing protein 82 (WDR82) is a ~35 kDa protein. Regulatory component of the SET1/COMPASS complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation. PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs). 1. Lee, JH. et al. (2008) Molecular and cellular biology 28, 609-18. PMID: 17998332 2. Wu, M. et al. (2008) Molecular and cellular biology 28, 7337-44. PMID: 18838538 3. Lee, JH. et al. (2010) The Journal of biological chemistry 285, 24466-76. PMID: 20516061 4. Wang, Z. et al. (2024) Molecular cell 84, 4824-4842.e7. PMID: 39603240 5. Kelley, JR. et al. (2024) Molecular cell 84, 4843-4861.e8. PMID: 39603239 6. Austenaa, LMI. et al. (2021) Nature structural & molecular biology 28, 337-346. PMID: 33767452 7. Estell, C. et al. (2021) eLife 10. PMID: 33913806 | ||||||||
| 注意事項 | For research use only |
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