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| カタログ番号 | HW294014 | ||||||||
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| 説明 |
Anti-WNT5A Polyclonal Antibody (HW294014) is a rabbit polyclonal antibody detecting WNT5A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Alopias vulpinus, and Ambystoma mexicanum.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human WNT5A (Ile62-Lys380). | ||||||||
| ターゲット | Protein Wnt-5a, WNT5A | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P41221 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein Wnt-5a (WNT5A) is a ~42 kDa protein. Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. 1. Kremenevskaja, N. et al. (2005) Oncogene 24, 2144-54. PMID: 15735754 2. Dissanayake, SK. et al. (2007) The Journal of biological chemistry 282, 17259-71. PMID: 17426020 | ||||||||
| 注意事項 | For research use only. |
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