Anti-XIAP Polyclonal Antibody (HX165014)

Name: Anti-XIAP Polyclonal Antibody
Brand: abinScience
SKU: HX165014
Price: 168 USD
Availability: InStock

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概要
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参考文献
データシート
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概要

カタログ番号

HX165014

説明

Anti-XIAP Polyclonal Antibody (HX165014) is a rabbit polyclonal antibody detecting XIAP in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human XIAP (Met1-Ser497).

ターゲット

ILP, IAP-like protein, X-linked inhibitor of apoptosis protein, IAP-3, hILP, X-linked IAP, Baculoviral IAP repeat-containing protein 4, Inhibitor of apoptosis protein 3, RING-type E3 ubiquitin transferase XIAP, E3 ubiquitin-protein ligase XIAP, API3, XIAP, hIAP-3, hIAP3, BIRC4, IAP3

精製

Purified by antigen affinity column.

アクセッション番号

P98170

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

E3 ubiquitin-protein ligase XIAP is a ~56 kDa protein. Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin.

1. Chai, J. et al. (2001) Cell 104, 769-80. PMID: 11257230

2. Huang, Y. et al. (2001) Cell 104, 781-90. PMID: 11257231

3. Suzuki, Y. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 8662-7. PMID: 11447297

4. MacFarlane, M. et al. (2002) The Journal of biological chemistry 277, 36611-6. PMID: 12121969

5. Shiozaki, EN. et al. (2003) Molecular cell 11, 519-27. PMID: 12620238

6. Lu, M. et al. (2007) Molecular cell 26, 689-702. PMID: 17560374

7. Wilkinson, JC. et al. (2008) Molecular and cellular biology 28, 237-47. PMID: 17967870

8. Van Themsche, C. et al. (2009) The Journal of biological chemistry 284, 20462-6. PMID: 19473982

9. Brady, GF. et al. (2010) Molecular and cellular biology 30, 1923-36. PMID: 20154138

10. Lewis, EM. et al. (2011) Biochemistry 50, 11084-96. PMID: 22103349

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-XIAP Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-XIAP Polyclonal Antibody (HX165014)

概要

イメージ

参考文献

データシート

SDS

クイックアクセス

お問い合わせ