

| Número de catálogo | HB640014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-XRCC1 Polyclonal Antibody (HB640014) is a rabbit polyclonal antibody detecting XRCC1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactividad de especies | Human | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human XRCC1 (Thr284-Ala633). | ||||||||
| Objetivo | DNA repair protein XRCC1, XRCC1, X-ray repair cross-complementing protein 1 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | P18887 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | DNA repair protein XRCC1 is a ~69 kDa protein. Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity. 1. Whitehouse, CJ. et al. (2001) Cell 104, 107-17. PMID: 11163244 2. Hoch, NC. et al. (2017) Nature 541, 87-91. PMID: 28002403 3. Demin, AA. et al. (2021) Molecular cell 81, 3018-3030.e5. PMID: 34102106 4. Adamowicz, M. et al. (2021) Nature cell biology 23, 1287-1298. PMID: 34811483 5. El-Khamisy, SF. et al. (2003) Nucleic acids research 31, 5526-33. PMID: 14500814 | ||||||||
| Nota | For research use only. |

Western blot analysis was performed using anti-XRCC1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
Lane 2: K562 cell lysate
Lane 3: Mouse testis lysate
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