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| カタログ番号 | MP332014 | ||||||||
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| 説明 |
Anti-YTHDF2 Polyclonal Antibody (MP332014) is a rabbit polyclonal antibody detecting YTH domain-containing family protein 2; Ythdf2 in ELISA, IHC, WB. Suitable for Bovine, Mouse, Zebrafish, and Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant mouse YTHDF2 (Pro385-Lys579). | ||||||||
| ターゲット | YTH domain-containing family protein 2; Ythdf2 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | E7F1H9, Q7Z739, Q9Y5A9, Q8BYK6, Q9BYJ9, Q0VCZ3, Q91YT7, P59326 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | YTH domain-containing family protein 2 (YTHDF2) is a ~66 kDa protein. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs. The YTHDF paralogs (ythdf1, ythdf2 and ythdf3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Plays a key role in maternal-to-zygotic transition during early embryonic development, the process during which maternally inherited mRNAs are degraded: acts by binding m6A-containing maternal mRNAs and promoting their degradation. 1. Zhao, BS. et al. (2017) Nature 542, 475-478. PMID: 28192787 2. Zhang, C. et al. (2017) Nature 549, 273-276. PMID: 28869969 | ||||||||
| 注意事項 | For research use only |
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