Anti-ZEBOV Glycoprotein Recombinant Nanobody (SAA1248) (VK623013)

Name: Anti-ZEBOV Glycoprotein Recombinant Nanobody (SAA1248)
Brand: abinScience
SKU: VK623013
Price: 191 USD
Availability: InStock

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Спецификация:

50ug
100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

VK623013

Описание

Anti-Zaire ebolavirus/ZEBOV GP/GP1, 2 Nanobody (SAA1248) [SAA1248] (VK623013) is a alpaca monoclonal antibody detecting GP1 in ELISA, SPR. Suitable for Zaire ebolavirus.

Реактивность видов

Zaire ebolavirus (ZEBOV) (Zaire Ebola virus)

Применения

ELISA, SPR

Хозяинский вид

Alpaca

Клоональность

Monoclonal

Изотип

VHH-8His-Cys-tag

ID клона

SAA1248

Цель

Envelope glycoprotein, GP, GP1, GP1,2, GP1,2-delta, GP2, Shed GP

Уровень эндотоксинов

< 10 EU/mg

Чистота

>95% as determined by SDS-PAGE.

Очистка

Purified by Nickel column.

Номер доступа

Q05320

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Envelope glycoprotein (GP) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity) (Probable). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes.

1. Simmons, G. et al. (2002) Journal of virology 76, 2518-28. PMID: 11836430

2. Takada, A. et al. (2000) Virology 278, 20-6. PMID: 11112476

3. Iampietro, M. et al. (2017) PLoS pathogens 13, e1006397. PMID: 28542576

4. Edri, A. et al. (2018) Frontiers in immunology 9, 1428. PMID: 30013549

5. Vande Burgt, NH. et al. (2015) Viruses 7, 5587-602. PMID: 26516900

6. Brinkmann, C. et al. (2016) Journal of virology 90, 11075-11086. PMID: 27707924

7. González-Hernández, M. et al. (2018) Journal of virology 92. PMID: 29669839

8. Rizk, MG. et al. (2017) Journal of virology 91. PMID: 28878074

Примечание

For research use only.

Изображения

SDS-PAGE

SDS-PAGE for Anti-Zaire ebolavirus/ZEBOV GP/GP1,2 Nanobody (SAA1248)

Ссылки

Даташит

Anti-ZEBOV Glycoprotein Recombinant Nanobody (SAA1248).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа