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| カタログ番号 | HW782014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ZAP70 Polyclonal Antibody (HW782014) is a rabbit polyclonal antibody detecting ZAP70 in ELISA, IHC, WB. Suitable for Mouse and Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ZAP70 (Leu337-Leu600). | ||||||||
| ターゲット | Tyrosine-protein kinase ZAP-70, ZAP70, Syk-related tyrosine kinase, 70 kDa zeta-chain associated protein, SRK | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P43403 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Tyrosine-protein kinase ZAP-70 (ZAP70) is a ~69 kDa protein. Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the phosphorylated TCR components CD3E and CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. 1. Iwashima, M. et al. (1994) Science (New York, N.Y.) 263, 1136-9. PMID: 7509083 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-ZAP70 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
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