Anti-ZC3H12A Polyclonal Antibody (HS805014)

Name: Anti-ZC3H12A Polyclonal Antibody
Brand: abinScience
SKU: HS805014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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SDS

Aperçu

Numéro de catalogue

HS805014

Description

Anti-ZC3H12A Polyclonal Antibody (HS805014) is a rabbit polyclonal antibody detecting ZC3H12A in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human ZC3H12A (Asp426-Glu599).

Cible

Regnase-1, MCPIP, Endoribonuclease ZC3H12A, Reg1, MCPIP-1, MCP-induced protein 1, ZC3H12A, Zinc finger CCCH domain-containing protein 12A, MCPIP1, Monocyte chemotactic protein-induced protein 1

Purification

Purified by antigen affinity column.

Numéro d'accès

Q5D1E8

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Endoribonuclease ZC3H12A is a ~65 kDa protein. Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs.

1. Mizgalska, D. et al. (2009) The FEBS journal 276, 7386-99. PMID: 19909337

2. Garg, AV. et al. (2015) Immunity 43, 475-87. PMID: 26320658

3. Xu, J. et al. (2012) Nucleic acids research 40, 6957-65. PMID: 22561375

4. Huang, S. et al. (2015) The Journal of biological chemistry 290, 20782-20792. PMID: 26134560

5. Suzuki, HI. et al. (2011) Molecular cell 44, 424-36. PMID: 22055188

6. Roy, A. et al. (2013) American journal of physiology. Cell physiology 305, C1021-32. PMID: 24048733

7. Wang, W. et al. (2015) The Journal of biological chemistry 290, 13372-85. PMID: 25861989

Note

For research use only.

Images

Reférences

Fiche technique

Anti-ZC3H12A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-ZC3H12A Polyclonal Antibody (HS805014)

Aperçu

Images

Reférences

Fiche technique

SDS