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| カタログ番号 | HS805014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ZC3H12A Polyclonal Antibody (HS805014) is a rabbit polyclonal antibody detecting ZC3H12A in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ZC3H12A (Asp426-Glu599). | ||||||||
| ターゲット | Regnase-1, MCPIP, Endoribonuclease ZC3H12A, Reg1, MCPIP-1, MCP-induced protein 1, ZC3H12A, Zinc finger CCCH domain-containing protein 12A, MCPIP1, Monocyte chemotactic protein-induced protein 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q5D1E8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Endoribonuclease ZC3H12A is a ~65 kDa protein. Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. 1. Mizgalska, D. et al. (2009) The FEBS journal 276, 7386-99. PMID: 19909337 2. Garg, AV. et al. (2015) Immunity 43, 475-87. PMID: 26320658 3. Xu, J. et al. (2012) Nucleic acids research 40, 6957-65. PMID: 22561375 4. Huang, S. et al. (2015) The Journal of biological chemistry 290, 20782-20792. PMID: 26134560 5. Suzuki, HI. et al. (2011) Molecular cell 44, 424-36. PMID: 22055188 6. Roy, A. et al. (2013) American journal of physiology. Cell physiology 305, C1021-32. PMID: 24048733 7. Wang, W. et al. (2015) The Journal of biological chemistry 290, 13372-85. PMID: 25861989 | ||||||||
| 注意事項 | For research use only. |
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