Anti-ZC3H12A Polyclonal Antibody (HS805014)

Name: Anti-ZC3H12A Polyclonal Antibody
Brand: abinScience
SKU: HS805014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HS805014

Описание

Anti-ZC3H12A Polyclonal Antibody (HS805014) is a rabbit polyclonal antibody detecting ZC3H12A in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human ZC3H12A (Asp426-Glu599).

Цель

Regnase-1, MCPIP, Endoribonuclease ZC3H12A, Reg1, MCPIP-1, MCP-induced protein 1, ZC3H12A, Zinc finger CCCH domain-containing protein 12A, MCPIP1, Monocyte chemotactic protein-induced protein 1

Очистка

Purified by antigen affinity column.

Номер доступа

Q5D1E8

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Endoribonuclease ZC3H12A is a ~65 kDa protein. Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs.

1. Mizgalska, D. et al. (2009) The FEBS journal 276, 7386-99. PMID: 19909337

2. Garg, AV. et al. (2015) Immunity 43, 475-87. PMID: 26320658

3. Xu, J. et al. (2012) Nucleic acids research 40, 6957-65. PMID: 22561375

4. Huang, S. et al. (2015) The Journal of biological chemistry 290, 20782-20792. PMID: 26134560

5. Suzuki, HI. et al. (2011) Molecular cell 44, 424-36. PMID: 22055188

6. Roy, A. et al. (2013) American journal of physiology. Cell physiology 305, C1021-32. PMID: 24048733

7. Wang, W. et al. (2015) The Journal of biological chemistry 290, 13372-85. PMID: 25861989

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-ZC3H12A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-ZC3H12A Polyclonal Antibody (HS805014)

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