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| カタログ番号 | HA293014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ZDHHC5 Polyclonal Antibody (HA293014) is a rabbit polyclonal antibody detecting ZDHHC5 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ZDHHC5 (Ser63-Tyr148). | ||||||||
| ターゲット | ZDHHC5, Palmitoyltransferase ZDHHC5, DHHC-5, Zinc finger DHHC domain-containing protein 5, ZNF375, KIAA1748, Zinc finger protein 375 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9C0B5 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Palmitoyltransferase ZDHHC5 is a ~77 kDa protein. Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions. Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins. Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2. Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2. 1. Kokkola, T. et al. (2011) FEBS letters 585, 2665-70. PMID: 21820437 2. Badawy, SMM. et al. (2017) Scientific reports 7, 16552. PMID: 29185452 3. Woodley, KT. et al. (2019) EMBO reports 20, e47472. PMID: 31402609 4. Lu, Y. et al. (2019) Science (New York, N.Y.) 366, 460-467. PMID: 31649195 5. Dixon, CL. et al. (2021) Journal of lipid research 62, 100097. PMID: 34293401 6. Zheng, S. et al. (2023) Molecular cell 83, 4570-4585.e7. PMID: 38092000 7. Balasubramanian, A. et al. (2024) Science immunology 9, eadn1452. PMID: 38530158 8. Du, G. et al. (2024) Nature 630, 437-446. PMID: 38599239 9. Brigidi, GS. et al. (2015) Nature communications 6, 8200. PMID: 26334723 10. Hao, JW. et al. (2020) Nature communications 11, 4765. PMID: 32958780 | ||||||||
| 注意事項 | For research use only. |
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