Anti-ZEBOV Glycoprotein Recombinant Antibody (GPE118) (VK623043)

Name: Anti-ZEBOV Glycoprotein Recombinant Antibody (GPE118)
Brand: abinScience
SKU: VK623043
Price: 191 USD
Availability: InStock

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Spécification :

50ug
100ug
1mg

Nombre :

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

VK623043

Reactivité des espèces

Zaire ebolavirus (ZEBOV) (Zaire Ebola virus)

Applications

ELISA, WB

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

IgG

ID de clone

GPE118

Cible

Envelope glycoprotein, GP, GP1, GP1,2, GP1,2-delta, GP2, Shed GP

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q05320

RRID

Anti-ZEBOV GP/Envelope glycoprotein Antibody (GPE118) (abinScience Cat# VK623043, RRID:AB_3727246)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Envelope glycoprotein (GP) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity) (Probable). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes.

1. Simmons, G. et al. (2002) Journal of virology 76, 2518-28. PMID: 11836430

2. Takada, A. et al. (2000) Virology 278, 20-6. PMID: 11112476

3. Iampietro, M. et al. (2017) PLoS pathogens 13, e1006397. PMID: 28542576

4. Edri, A. et al. (2018) Frontiers in immunology 9, 1428. PMID: 30013549

5. Vande Burgt, NH. et al. (2015) Viruses 7, 5587-602. PMID: 26516900

6. Brinkmann, C. et al. (2016) Journal of virology 90, 11075-11086. PMID: 27707924

7. González-Hernández, M. et al. (2018) Journal of virology 92. PMID: 29669839

8. Rizk, MG. et al. (2017) Journal of virology 91. PMID: 28878074

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-ZEBOV GP/Envelope glycoprotein Antibody (GPE118)

Reférences

Fiche technique

Anti-ZEBOV Glycoprotein Recombinant Antibody (GPE118).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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