Anti-ZEBOV Glycoprotein Recombinant Antibody (mAb100) (VK623023)

Name: Anti-ZEBOV Glycoprotein Recombinant Antibody (mAb100)
Brand: abinScience
SKU: VK623023
Price: 126 USD
Availability: InStock

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1mg

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

VK623023

Reactivité des espèces

Zaire ebolavirus (ZEBOV) (Zaire Ebola virus)

Applications

ELISA

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

IgG

ID de clone

mAb100

Cible

Envelope glycoprotein, GP, GP1, GP1,2, GP1,2-delta, GP2, Shed GP

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q05320

RRID

Anti-ZEBOV GP/Envelope glycoprotein Antibody (mAb100) (abinScience Cat# VK623023, RRID:AB_3727244)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Envelope glycoprotein (GP) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes.

Note

For research use only.

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