Anti-ZEBOV Glycoprotein Neutralization Recombinant Antibody (KZ52) (VK623053)

Name: Anti-ZEBOV Glycoprotein Neutralization Recombinant Antibody (KZ52)
Brand: abinScience
SKU: VK623053
Price: 191 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

VK623053

Reactividad de especies

Zaire ebolavirus (ZEBOV) (Zaire Ebola virus)

Aplicaciones

ELISA, WB

Especie huésped

Human

Clonalidad

Monoclonal

Isotipo

IgG

ID de clon

KZ52

Objetivo

Envelope glycoprotein, GP, GP1, GP1,2, GP1,2-delta, GP2, Shed GP

Nivel de endotoxinas

< 10 EU/mg

Pureza

>90% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q05320

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Envelope glycoprotein (GP) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity) (Probable). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes.

1. Simmons, G. et al. (2002) Journal of virology 76, 2518-28. PMID: 11836430

2. Takada, A. et al. (2000) Virology 278, 20-6. PMID: 11112476

3. Iampietro, M. et al. (2017) PLoS pathogens 13, e1006397. PMID: 28542576

4. Edri, A. et al. (2018) Frontiers in immunology 9, 1428. PMID: 30013549

5. Vande Burgt, NH. et al. (2015) Viruses 7, 5587-602. PMID: 26516900

6. Brinkmann, C. et al. (2016) Journal of virology 90, 11075-11086. PMID: 27707924

7. González-Hernández, M. et al. (2018) Journal of virology 92. PMID: 29669839

8. Rizk, MG. et al. (2017) Journal of virology 91. PMID: 28878074

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-ZEBOV GP/Envelope glycoprotein Neutralization Antibody (KZ52)

Referencias

Datasheet

Anti-ZEBOV Glycoprotein Neutralization Recombinant Antibody (KZ52).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo