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| カタログ番号 | VK518023 | ||||
|---|---|---|---|---|---|
| 種反応性 | Zaire ebolavirus (ZEBOV) (Zaire Ebola virus) | ||||
| アプリケーション | ELISA, IF | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG | ||||
| クローンID | KZ51 | ||||
| ターゲット | NP, Nucleoprotein, Nucleocapsid protein | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P18272 | ||||
| RRID | Anti-ZEBOV NP/Nucleoprotein Antibody (KZ51) (abinScience Cat# VK518023, RRID:AB_3727247) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Nucleoprotein (NP) is a ~83 kDa protein. Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response. VP35 binds to and stabilizes monomeric NP, keeping it soluble. Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. The nucleocapsid is helical with a pitch of 10.81 NP per turn and a diameter of about 22nm. 1. Johnson, RF. et al. (2006) Virology journal 3, 31. PMID: 16719918 2. Leung, DW. et al. (2015) Cell reports 11, 376-89. PMID: 25865894 3. Kirchdoerfer, RN. et al. (2015) Cell reports 12, 140-149. PMID: 26119732 4. Sugita, Y. et al. (2018) Nature 563, 137-140. PMID: 30333622 5. Wan, W. et al. (2017) Nature 551, 394-397. PMID: 29144446 6. Beniac, DR. et al. (2012) PloS one 7, e29608. PMID: 22247782 7. Kirchdoerfer, RN. et al. (2016) PLoS pathogens 12, e1005937. PMID: 27755595 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-ZEBOV NP/Nucleoprotein Antibody (KZ51)
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