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| カタログ番号 | VK661013 | ||||||
|---|---|---|---|---|---|---|---|
| 種反応性 | Zaire ebolavirus (ZEBOV) (Zaire Ebola virus) | ||||||
| アプリケーション | ELISA, WB | ||||||
| 宿主種 | Human | ||||||
| クローン性 | Monoclonal | ||||||
| アイソタイプ | IgG | ||||||
| クローンID | F9 | ||||||
| ターゲット | VP35, Polymerase cofactor VP35, Ebola VP35, eVP35 | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||||
| アクセッション番号 | Q05127 | ||||||
| RRID | Anti-ZEBOV VP35/Polymerase cofactor VP35 Antibody (F9) (abinScience Cat# VK661013, RRID:AB_3727248) |
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| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| 背景 | Polymerase cofactor VP35 is a ~37 kDa protein. Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Part of the external layer of the nucleocapsid, likely tethering the nucleocapsid to the matrix and membrane. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. 1. Basler, CF. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 12289-94. PMID: 11027311 2. van Tol, S. et al. (2022) PLoS pathogens 18, e1010532. PMID: 35533195 3. Enterlein, S. et al. (2006) Antimicrobial agents and chemotherapy 50, 984-93. PMID: 16495261 4. Brown, CS. et al. (2014) Journal of molecular biology 426, 2045-58. PMID: 24495995 5. Mühlberger, E. et al. (1999) Journal of virology 73, 2333-42. PMID: 9971816 6. Watanabe, R. et al. (2024) Cell 187, 5587-5603.e19. PMID: 39293445 7. Luthra, P. et al. (2015) Journal of virology 89, 5148-53. PMID: 25741013 8. Leung, DW. et al. (2015) Cell reports 11, 376-89. PMID: 25865894 9. Yen, BC. et al. (2016) Journal of virology 90, 5108-5118. PMID: 26962215 10. Luthra, P. et al. (2013) Cell host & microbe 14, 74-84. PMID: 23870315 | ||||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-ZEBOV VP35/Polymerase cofactor VP35 Antibody (F9)
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