HEK293T Human CD37/TSPAN26 Stable Cell Line (HY564818)

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Número de catálogo	HY564818
Descripción	HEK293T Human CD37/TSPAN26 Stable Cell Line (HY564818) is a stable cell line expressing CD37/TSPAN26. Engineered for consistent, high-level target expression in research applications. Highlights ●Stable Expression — Engineered for consistent, high-level target expression.
Número de acceso	P11049
Aplicaciones	FCM
Especie huésped	HEK293T
Especies	Human
Objetivo	CD37/TSPAN26
Propiedades	Growth Properties: Adherent; Selection Marker: Puromycin (1 μg/mL)
Estabilidad y almacenamiento	Frozen in liquid nitrogen.
Especificaciones	1 vial contains at least 2×10^6 cells in 1 mL Freeze Medium
Fondo	Leukocyte antigen CD37 (TSPAN26) is a ~31 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT. 1. Lapalombella, R. et al. (2012) Cancer cell 21, 694-708. PMID: 22624718 2. de Winde, CM. et al. (2016) The Journal of clinical investigation 126, 653-66. PMID: 26784544 3. Meyer-Wentrup, F. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 178, 154-62. PMID: 17182550

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Flow cytometry

Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human CD37 monoclonal antibody at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

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