HEK293T Human CD46 Stable Cell Line (HB735818)

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Каталожный номер	HB735818
Описание	HEK293T Mouse CD46 Stable Cell Line (HB735818) is a stable cell line expressing CD46. Engineered for consistent, high-level target expression in research applications. Highlights ●Stable Expression — Engineered for consistent, high-level target expression.
Номер доступа	P15529
Применения	FCM
Хозяинский вид	HEK293T
Виды	Mouse
Цель	CD46
Метод обнаружения	Colorimetric
Тип образца	Plasma, Serum
Тип анализа	Quantitative
Диапазон	1.56 - 100 ng/mL
Чувствительность	0.25 ng/mL
Восстановление	80-120%
Свойства	Growth Properties: Adherent; Selection Marker: Puromycin (1 μg/mL)
Доставка	2-8 ℃
Устойчивость и хранение	Frozen in liquid nitrogen.
Характеристики	1 vial contains at least 2×10^6 cells in 1 mL Freeze Medium
Фон	Membrane cofactor protein (CD46) is a ~43 kDa protein. Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
Примечание	For research use only

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Flow cytometry

Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human CD46 monoclonal antibody at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

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