InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135) (ZP769010)

Name: InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135)
Brand: abinScience
SKU: ZP769010
Price: 370 USD
Availability: InStock

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100ug
1mg

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Vista general

Número de catálogo	ZP769010
Descripción	InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135) [Iv0135] (ZP769010) is a human monoclonal antibody detecting Beta-mammal/insect toxin Ts1 in ELISA, Neutralization.
Reactividad de especies	Tityus serrulatus (Brazilian scorpion)
Aplicaciones	ELISA, Neutralization
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	Iv0135
Objetivo	Beta-mammal/insect toxin Ts1, Beta-like toxin Ts1, PT-Mice-Ins-beta NaTx6.1, Tityustoxin VII, Toxin VII, Ts VII, Ts7, TsTX-VII, Toxin II-11, Toxin III-10, Toxin T2-IV, Toxin gamma, T-gamma, TiTx gamma, Toxin-g, TsTX-I
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Productos asociados	pH 7.4 Dilution Buffer
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P15226
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Beta-mammal/insect toxin Ts1 (Tityustoxin VII/Toxin VII) is a ~9 kDa protein. Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements. Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1). 1. Peigneur, S. et al. (2015) Neuropharmacology 95, 269-77. PMID: 25862296 2. Campos, FV. et al. (2007) The Journal of general physiology 130, 257-68. PMID: 17698594 3. Bosmans, F. et al. (2008) Nature 456, 202-8. PMID: 19005548 4. Martin-Eauclaire, MF. et al. (2015) The Journal of general physiology 145, 155-62. PMID: 25624450 5. Bosmans, F. et al. (2011) The Journal of general physiology 138, 59-72. PMID: 21670206 6. Dang, B. et al. (2014) Angewandte Chemie (International ed. in English) 53, 8970-4. PMID: 24989851
Nota	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135)

Referencias

Datasheet

InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135).pdf

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Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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