InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135) (ZP769010)

Name: InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135)
Brand: abinScience
SKU: ZP769010
Price: 370 USD
Availability: InStock

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Numéro de catalogue	ZP769010
Description	InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135) [Iv0135] (ZP769010) is a human monoclonal antibody detecting Beta-mammal/insect toxin Ts1 in ELISA, Neutralization.
Reactivité des espèces	Tityus serrulatus (Brazilian scorpion)
Applications	ELISA, Neutralization
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	Iv0135
Cible	Beta-mammal/insect toxin Ts1, Beta-like toxin Ts1, PT-Mice-Ins-beta NaTx6.1, Tityustoxin VII, Toxin VII, Ts VII, Ts7, TsTX-VII, Toxin II-11, Toxin III-10, Toxin T2-IV, Toxin gamma, T-gamma, TiTx gamma, Toxin-g, TsTX-I
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>95% as determined by SDS-PAGE.
Produits associés	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P15226
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Beta-mammal/insect toxin Ts1 (Tityustoxin VII/Toxin VII) is a ~9 kDa protein. Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements. Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1). 1. Peigneur, S. et al. (2015) Neuropharmacology 95, 269-77. PMID: 25862296 2. Campos, FV. et al. (2007) The Journal of general physiology 130, 257-68. PMID: 17698594 3. Bosmans, F. et al. (2008) Nature 456, 202-8. PMID: 19005548 4. Martin-Eauclaire, MF. et al. (2015) The Journal of general physiology 145, 155-62. PMID: 25624450 5. Bosmans, F. et al. (2011) The Journal of general physiology 138, 59-72. PMID: 21670206 6. Dang, B. et al. (2014) Angewandte Chemie (International ed. in English) 53, 8970-4. PMID: 24989851
Note	For research use only. Not suitable for clinical or therapeutic use.

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InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135).pdf

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