InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135) (ZP769010)

Name: InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135)
Brand: abinScience
SKU: ZP769010
Price: 370 USD
Availability: InStock

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100ug
1mg

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Каталожный номер	ZP769010
Описание	InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135) [Iv0135] (ZP769010) is a human monoclonal antibody detecting Beta-mammal/insect toxin Ts1 in ELISA, Neutralization.
Реактивность видов	Tityus serrulatus (Brazilian scorpion)
Применения	ELISA, Neutralization
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	Iv0135
Цель	Beta-mammal/insect toxin Ts1, Beta-like toxin Ts1, PT-Mice-Ins-beta NaTx6.1, Tityustoxin VII, Toxin VII, Ts VII, Ts7, TsTX-VII, Toxin II-11, Toxin III-10, Toxin T2-IV, Toxin gamma, T-gamma, TiTx gamma, Toxin-g, TsTX-I
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Связанные продукты	pH 7.4 Dilution Buffer
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P15226
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Beta-mammal/insect toxin Ts1 (Tityustoxin VII/Toxin VII) is a ~9 kDa protein. Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements. Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1). 1. Peigneur, S. et al. (2015) Neuropharmacology 95, 269-77. PMID: 25862296 2. Campos, FV. et al. (2007) The Journal of general physiology 130, 257-68. PMID: 17698594 3. Bosmans, F. et al. (2008) Nature 456, 202-8. PMID: 19005548 4. Martin-Eauclaire, MF. et al. (2015) The Journal of general physiology 145, 155-62. PMID: 25624450 5. Bosmans, F. et al. (2011) The Journal of general physiology 138, 59-72. PMID: 21670206 6. Dang, B. et al. (2014) Angewandte Chemie (International ed. in English) 53, 8970-4. PMID: 24989851
Примечание	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135)

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InVivoMAb Anti-Brazilian scorpion Tityustoxin VII/Toxin VII/Ts7 Antibody (Iv0135).pdf

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